H2N2V1, Main, Exploration, bibRecord, 001236

Origin of the 1918 Spanish influenza virus: a comparative genomic analysis.

Identifieur interne : 001236 ( Main/Exploration ); précédent : 001235; suivant : 001237

Origin of the 1918 Spanish influenza virus: a comparative genomic analysis.

Auteurs : Geoff Vana [États-Unis] ; Kristi M. Westover

Source :

Molecular phylogenetics and evolution [ 1055-7903 ] ; 2008.

RBID : pubmed:18353690

Descripteurs français

KwdFr :
- ADN concaténé (génétique), Espagne, Génome viral (génétique), Humains, Phylogénie, Virus de la grippe A (génétique).
MESH :
- génétique : ADN concaténé, Génome viral, Virus de la grippe A.
- Espagne, Humains, Phylogénie.
Wicri :
- geographic : Espagne.

English descriptors

KwdEn :
- DNA, Concatenated (genetics), Genome, Viral (genetics), Humans, Influenza A virus (genetics), Phylogeny, Spain.
MESH :
- chemical , genetics : DNA, Concatenated.
- geographic : Spain.
- genetics : Genome, Viral, Influenza A virus.
- Humans, Phylogeny.

Abstract

To test the avian-origin hypothesis of the 1918 Spanish influenza virus we surveyed influenza sequences from a broad taxonomic distribution and collected 65 full-length genomes representing avian, human and "classic" swine H1N1 lineages in addition to numerous other swine (H1N2, H3N1, and H3N2), human (H2N2, H3N2, and H5N1), and avian (H1N1, H4N6, H5N1, H6N1, H6N6, H6N8, H7N3, H8N4, H9N2, and H13N2) subtypes. Amino acids from all eight segments were concatenated, aligned, and used for phylogenetic analyses. In addition, the genes of the polymerase complex (PB1, PB2, and PA) were analyzed individually. All of our results showed the Brevig-Mission/1918 strain in a position basal to the rest of the clade containing human H1N1s and were consistent with a reassortment hypothesis for the origin of the 1918 virus. Our genome phylogeny further indicates a sister relationship with the "classic" swine H1N1 lineage. The individual PB1, PB2, and PA phylogenies were consistent with reassortment/recombination hypotheses for these genes. These results demonstrate the importance of using a complete-genome approach for addressing the avian-origin hypothesis and predicting the emergence of new pandemic influenza strains.

DOI: 10.1016/j.ympev.2008.02.003
PubMed: 18353690

Affiliations:

États-Unis

Le document en format XML

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<term>Phylogeny</term>
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<front><div type="abstract" xml:lang="en">To test the avian-origin hypothesis of the 1918 Spanish influenza virus we surveyed influenza sequences from a broad taxonomic distribution and collected 65 full-length genomes representing avian, human and "classic" swine H1N1 lineages in addition to numerous other swine (H1N2, H3N1, and H3N2), human (H2N2, H3N2, and H5N1), and avian (H1N1, H4N6, H5N1, H6N1, H6N6, H6N8, H7N3, H8N4, H9N2, and H13N2) subtypes. Amino acids from all eight segments were concatenated, aligned, and used for phylogenetic analyses. In addition, the genes of the polymerase complex (PB1, PB2, and PA) were analyzed individually. All of our results showed the Brevig-Mission/1918 strain in a position basal to the rest of the clade containing human H1N1s and were consistent with a reassortment hypothesis for the origin of the 1918 virus. Our genome phylogeny further indicates a sister relationship with the "classic" swine H1N1 lineage. The individual PB1, PB2, and PA phylogenies were consistent with reassortment/recombination hypotheses for these genes. These results demonstrate the importance of using a complete-genome approach for addressing the avian-origin hypothesis and predicting the emergence of new pandemic influenza strains.</div>
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Origin of the 1918 Spanish influenza virus: a comparative genomic analysis.

Origin of the 1918 Spanish influenza virus: a comparative genomic analysis.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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